diff --git a/Common/CPUDetect.cpp b/Common/CPUDetect.cpp
index cb50ce8079..96cf1319a2 100644
--- a/Common/CPUDetect.cpp
+++ b/Common/CPUDetect.cpp
@@ -30,7 +30,7 @@
 #include "CPUDetect.h"
 #include "StringUtils.h"
 
-#ifdef _WIN32
+#if defined(_WIN32) && !defined(__MINGW32__)
 #define WIN32_LEAN_AND_MEAN
 #include <Windows.h>
 #define _interlockedbittestandset workaround_ms_header_bug_platform_sdk6_set
diff --git a/Common/Common.h b/Common/Common.h
index 187b36858a..ec69b6022b 100644
--- a/Common/Common.h
+++ b/Common/Common.h
@@ -96,4 +96,4 @@
 # elif defined __SSE2__
 #  define _M_SSE 0x200
 # endif
-#endif
\ No newline at end of file
+#endif
diff --git a/Common/CommonFuncs.h b/Common/CommonFuncs.h
index 77f466bcd4..b8a9aea66d 100644
--- a/Common/CommonFuncs.h
+++ b/Common/CommonFuncs.h
@@ -70,9 +70,11 @@ inline u64 __rotr64(u64 x, unsigned int shift){
 	#define __rotr64 _rotr64
 
 // 64 bit offsets for windows
+#ifndef __MINGW32__
 	#define fseeko _fseeki64
 	#define ftello _ftelli64
 	#define atoll _atoi64
+#endif
 	#if _M_IX86
 		#define Crash() {__asm int 3}
 	#else
diff --git a/Core/HLE/sceRtc.cpp b/Core/HLE/sceRtc.cpp
index 43cbdc5ee9..b5b4cfe807 100644
--- a/Core/HLE/sceRtc.cpp
+++ b/Core/HLE/sceRtc.cpp
@@ -74,6 +74,22 @@ static u64 __RtcGetCurrentTick()
 	return CoreTiming::GetGlobalTimeUs() + rtcBaseTicks;
 }
 
+#if defined(__MINGW32__)
+errno_t _get_timezone(long *seconds)
+{
+  time_t now = time(NULL);
+
+  struct tm *gm = gmtime(&now);
+  time_t gmt = mktime(gm);
+
+  struct tm *loc = localtime(&now);
+  time_t local = mktime(loc);
+
+  *seconds = local - gmt;
+  return 0;
+}
+#endif
+
 #if defined(_WIN32)
 #define FILETIME_FROM_UNIX_EPOCH_US (rtcMagicOffset - rtcFiletimeOffset)
 
diff --git a/Core/MIPS/JitCommon/JitCommon.cpp b/Core/MIPS/JitCommon/JitCommon.cpp
index 7c0289f07e..55409c77c6 100644
--- a/Core/MIPS/JitCommon/JitCommon.cpp
+++ b/Core/MIPS/JitCommon/JitCommon.cpp
@@ -61,7 +61,7 @@ namespace MIPSComp {
 	}
 
 }
-#if PPSSPP_PLATFORM(WINDOWS)
+#if PPSSPP_PLATFORM(WINDOWS) && !defined(__LIBRETRO__)
 #define DISASM_ALL 1
 #endif
 
diff --git a/Core/System.cpp b/Core/System.cpp
index 05e47333eb..04c93deeb1 100644
--- a/Core/System.cpp
+++ b/Core/System.cpp
@@ -650,7 +650,11 @@ void InitSysDirectories() {
 
 	// If installed.txt exists(and we can determine the Documents directory)
 	if (installed && (result == S_OK))	{
+#if defined(_WIN32) && defined(__MINGW32__)
+		std::ifstream inputFile(installedFile);
+#else
 		std::ifstream inputFile(ConvertUTF8ToWString(installedFile));
+#endif
 
 		if (!inputFile.fail() && inputFile.is_open()) {
 			std::string tempString;
diff --git a/GPU/GPU.cpp b/GPU/GPU.cpp
index 0cd5c85c49..72f6bf1f4a 100644
--- a/GPU/GPU.cpp
+++ b/GPU/GPU.cpp
@@ -71,14 +71,14 @@ bool GPU_Init(GraphicsContext *ctx, Draw::DrawContext *draw) {
 		SetGPU(new SoftGPU(ctx, draw));
 		break;
 	case GPUCORE_DIRECTX9:
-#if defined(_WIN32)
+#if defined(_WIN32) && !defined(__LIBRETRO__)
 		SetGPU(new DIRECTX9_GPU(ctx, draw));
 		break;
 #else
 		return false;
 #endif
 	case GPUCORE_DIRECTX11:
-#if defined(_WIN32)
+#if defined(_WIN32) && !defined(__LIBRETRO__)
 		SetGPU(new GPU_D3D11(ctx, draw));
 		break;
 #else
diff --git a/ext/native/ext/libzip/mkstemp.c b/ext/native/ext/libzip/mkstemp.c
index 0dbaaf0572..c61e279f9d 100644
--- a/ext/native/ext/libzip/mkstemp.c
+++ b/ext/native/ext/libzip/mkstemp.c
@@ -45,7 +45,7 @@
 #include <stdio.h>
 #include <stdlib.h>
 
-#ifdef _WIN32
+#if defined(_WIN32) && !defined(__MINGW32__)
 typedef int pid_t;
 #define getpid rand
 #endif
diff --git a/ext/native/gfx_es2/gpu_features.cpp b/ext/native/gfx_es2/gpu_features.cpp
index 92f8c75c68..a97a0f39f4 100644
--- a/ext/native/gfx_es2/gpu_features.cpp
+++ b/ext/native/gfx_es2/gpu_features.cpp
@@ -264,6 +264,7 @@ void CheckGLExtensions() {
 		}
 	}
 
+#ifndef __LIBRETRO__
 #ifdef WIN32
 	const char *wglString = 0;
 	if (wglGetExtensionsStringEXT)
@@ -277,6 +278,7 @@ void CheckGLExtensions() {
 #elif !defined(USING_GLES2)
 	// const char *glXString = glXQueryExtensionString();
 	// gl_extensions.EXT_swap_control_tear = strstr(glXString, "GLX_EXT_swap_control_tear") != 0;
+#endif
 #endif
 
 	// Check the desktop extension instead of the OES one. They are very similar.
diff --git a/ext/native/thread/threadutil.cpp b/ext/native/thread/threadutil.cpp
index 87a22ffa14..fcd050e98f 100644
--- a/ext/native/thread/threadutil.cpp
+++ b/ext/native/thread/threadutil.cpp
@@ -20,10 +20,52 @@
 static __THREAD const char *curThreadName;
 #endif
 
+#ifdef __MINGW32__
+#include <pshpack8.h>
+typedef struct {
+	DWORD dwType;
+	LPCSTR szName;
+	DWORD dwThreadID;
+	DWORD dwFlags;
+} THREADNAME_INFO;
+#include <poppack.h>
+
+static EXCEPTION_DISPOSITION NTAPI ignore_handler(EXCEPTION_RECORD *rec,
+                                                  void *frame, CONTEXT *ctx,
+                                                  void *disp)
+{
+	return ExceptionContinueExecution;
+}
+#endif
+
 void setCurrentThreadName(const char* threadName) {
 #ifdef _WIN32
 	// Set the debugger-visible threadname through an unholy magic hack
 	static const DWORD MS_VC_EXCEPTION = 0x406D1388;
+#endif
+
+#if defined(_WIN32) && defined(__MINGW32__)
+	// Thread information for VS compatible debugger. -1 sets current thread.
+	THREADNAME_INFO ti;
+	ti.dwType = 0x1000;
+	ti.szName = threadName;
+	ti.dwThreadID = -1;
+
+	// Push an exception handler to ignore all following exceptions
+	NT_TIB *tib = ((NT_TIB*)NtCurrentTeb());
+	EXCEPTION_REGISTRATION_RECORD rec;
+	rec.Next = tib->ExceptionList;
+	rec.Handler = ignore_handler;
+	tib->ExceptionList = &rec;
+
+	// Visual Studio and compatible debuggers receive thread names from the
+	// program through a specially crafted exception
+	RaiseException(MS_VC_EXCEPTION, 0, sizeof(ti) / sizeof(ULONG_PTR),
+	               (ULONG_PTR*)&ti);
+
+	// Pop exception handler
+	tib->ExceptionList = tib->ExceptionList->Next;
+#elif defined(_WIN32)
 #pragma pack(push,8)
 	struct THREADNAME_INFO {
 		DWORD dwType; // must be 0x1000